Role of mitral annular plane systolic excursion and e- point septal separation for evaluation of left ventricular systolic dysfunction in patients with septic shock.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- To analyze MAPSE for identifying patients with left
研究概览
简要总结
This study is prospective, observational, cohort study which will be conducted in the critical care department at Holy Family Hospital, New Delhi to evaluate accuracy of MAPSE and EPSS for prediction of left ventricular systolic dysfunction in septic shock using point of care ultrasound. Patients above or equal the age of 18 years old admitted with septic shock after satisfying the eligibility criteria and willing to participate in the study will be recruited after obtaining written informed consent. After collecting the demographic information and diagnosis, patients in septic shock will be resuscitated in accordance with the hospital protocol and as per the dynamic markers of fluid resuscitation. Bedside echocardiography will be done after adequate fluid resuscitation within 24 hours of presentation by two different operators to know the contractility of heart and findings will be noted. No intervention shall be done for study. Data regarding the investigation reports and patient outcome will be recorded form ICU charts. The study aims to see how well MAPSE and EPSS correlate with LVEF and GLS in detecting left ventricular dysfunction, making them reliable and faster alternatives for critical care assessments.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Age more than or equal to 18 years of age admitted with sepsis in ICU meeting Sepsis 3.0 criteria.
- •Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.
- •For clinical operationalization, organ dysfunction will be represented by an increase in the Sequential (Sepsis-related) Organ Failure Assessment (SOFA) score of 2 points or more.
- •Patients with septic shock can be clinically identified by 1.vasopressor requirement to maintain a mean arterial pressure of 65 mm Hg or greater 2.serum lactate level greater than 2 mmol per litre (more than 18 mg per dL) in the absence of hypovolemia.
排除标准
- •Moderate to severe mitral or aortic valvulopathy
- •Prosthetic valves
- •Significant arrythmias
- •Pregnant patient
- •Inadequate ECHO image quality
- •Not willing for consent.
结局指标
主要结局
To analyze MAPSE for identifying patients with left
时间窗: Within 24hrs of Presentation
ventricular systolic dysfunction denoted by LVEF less than 50%, an absolute GLS lesser than 17% or both.
时间窗: Within 24hrs of Presentation
次要结局
- To analyze EPSS for identifying patients with left(ventricular systolic dysfunction denoted by LVEF less than 50%, an absolute GLS lesser than 17% or both.)
- Comparing MAPSE and EPSS in identifying left ventricular systolic dysfunction(in septic shock patients.)
研究者
Dr Anuradha Gajraj
Holy Family Hospital