The study evaluating the effects of pravastatin and atrovastatin on regulation of small GTP-binding proteins in huma
Not Applicable
- Conditions
- Atherosclerotic cardiovascular diseases
- Registration Number
- JPRN-UMIN000005105
- Lead Sponsor
- Department of cardiovascular medicine, Tohoku university graduate school of medicine
- Brief Summary
In normal healthy volunteers, statins significantly increased SmgGDS expression with a significant negative correlation between SmgGDS expression and oxidative stress markers, whereas no correlation was noted with total or low-density lipoprotein-cholesterol.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1) Pregnant or possibly pregnant individuals 2) Current smorker or history of smoking
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expression of SmgGDS in human leucocytes
- Secondary Outcome Measures
Name Time Method 1)Expressions and activities of small GTP binding proteins 2)Serum levels of total cholesterol, LDL cholesterol, triglyceride,MDA-LDL, and RLP-C 3) Bio-markers for oxidant stress (8-isoprostane and PTX-3) 4) Urinary cyclic GMP, 8-isoprostane, and 8-OHdG