Comparison of the effect of acetazolamide and paracetamol on referred postoperative pain after laparoscopic gallbladder surgery
Phase 2
- Conditions
- Cholecystitis.Cholecystitis
- Registration Number
- IRCT201206108384N2
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 114
Inclusion Criteria
Inclusion Criteria
1- Patients candidates for laparoscopic cholecystectomy
Excusion Criteria
1- Patients with pain disorder
2- Intraoperative complications such as cystic artery bleeding, leakage of bile into the peritoneal cavity
3- Postoperative complications such as bile duct injury, bile leakage, or biliary ascites.
4- Consumption of any narcotics and analgesics within 1 or 2 days before surgery.
5- Narcotics addicts
6- Contraindications to acetaminophen and acetasolamide, also lactose and starch (as components of the placebo)
7- Presence of inflammation, adhesions and excessive dissection which may prolong the operative time for more than 1 hours
8- The need for drain insertion
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity. Timepoint: Immediately before and after surgery, after return of consciousness, at the time of stay in post-operative care unit, during 24 hours stay in the ward and at the time of discharge. Method of measurement: Visual Analog Scale (VAS).;Pain location. Timepoint: Immediately before and after surgery, after return of consciousness, at the time of stay in post-operative care unit, during 24 hours stay in the ward and at the time of discharge. Method of measurement: Objectively.
- Secondary Outcome Measures
Name Time Method Analgesic consumption. Timepoint: Immediately before and/or after surgery and/or after return of consciousness and/or at the time of stay in post-operative care unit and/or during 24 hours stay in the ward and/or at the time of discharge. Method of measurement: mg.