Acetazolamide and Topiramate on patients with traumatic cerebrospinal fluid leakage

Phase 2

Recruiting

• Conditions: Brain Trauma.; Diffuse traumatic brain injury; S06.2

• Registration Number: IRCT20221108056446N4
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patient consent to enter the study
The patient's non-use of Tricyclic Antidepressants and carbonic anhydrase inhibitor in order to prevent drug interactions.

Exclusion Criteria

Patients who develop meningitis and brain abscess
Patients with severe electrolyte disturbances
Patients who do not respond to treatment and have to use brain surgery
Patients who did not respond to drug therapy after one week and another intervention should be performed on them
Failure to visit the patient for follow-up
Kidney and liver patients who are suffering from a specific disease based on the diagnosis of a specialist and are listed in the patient's medical record

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebrospinal fluid leakage. Timepoint: Patients are evaluated weekly using a checklist and up to three months after discharge from the hospital. Method of measurement: Checklist and measurement of GCS.