To compare the effectiveness of oral drugs Acetazolamide and Topiramate in post surgery cases of spontaneous brain fluid leaks
Phase 2
- Conditions
- Health Condition 1: R299- Unspecified symptoms and signs involving the nervous and musculoskeletal systems
- Registration Number
- CTRI/2024/07/070355
- Lead Sponsor
- Dr Devendra Shekhawat
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients who are diagnosed as spontaneous CSF rhinorrhea and who
will undergo Endoscopic repair of the leak.
All sexes.
Revision Endoscopic repair of defect.
Exclusion Criteria
Patients with other causes of CSF rhinorrhea.
Patients who develop intraop complications which require specific post op management.
Patients who develop post op meningitis.
Patients who do not give consent for the study.
Patients who fail to turn up for follow up assessment.
Any contraindication to Magnetic resonance (MR) imaging.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Topiramate is a better drug in comparison to Acetazolamide in reducing CSF pressure in post op patients who underwent endoscopic repair of spontaneous CSF leaks.Timepoint: 1 month 3 months and 6 months
- Secondary Outcome Measures
Name Time Method either drug being better in terms of complaince, cost effectiveness and side effect profile at maximum tolerable dose.Timepoint: 1 month 3 months and 6 months