The Effect of Magnesium Supplementation During General Anesthesia on the Quality of Postoperative Recovery in Children
- Registration Number
- NCT03132701
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Evaluation of prevention of emergence delirium and analgesic effect of magnesium on children
- Detailed Description
Children \< 8 years old who scheduled for elective opthalmic surgery are randomly assigned to Magnesium (Mg) group and control group. Before anesthetic induction, modified Yale Preoperative Anxiety Scale (m-YPAS) is assessed. Routine anesthetic induction is performed, and neuromuscular blocker is not used. Laryngeal mask airway is inserted and controlled ventilation is started.
In Mg group, Mg of 30 mg/kg is administered for 10 minutes and then continuously infused (10mg/kg/hr) until 5 minutes before surgery end. In control group, the similar volume of saline is infused.
Pediatric Anesthesia Emergence Delirium (PAED) scale and pain score (Modified Children's Hospital of Eastern Ontario Pain Scale, CHEOPS) will be measured immediately after and 30 minutes after surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 66
- Children aged between 2 and 7 years
- American Society of Anesthesiologist physical status 1 and 2
- Children scheduled for opthalmic surgery
- Allergy history to any drugs
- Risk of malignant hyperthermia
- Neuromuscular disease
- With arrhythmia
- Any pulmonary, cardiac, hepatic and renal disease
- Obesity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Saline Saline is administered with same volume of Mg of magnesium group until 5 minutes before surgery ends Magnesium group Magnesium Mg is administered with dose of 30 mg/kg for 10 minutes and then 10 mg/kg/hr until 5 minutes before surgery ends
- Primary Outcome Measures
Name Time Method Emergence delirium 30 minutes after anesthesia Pediatric Anesthesia Emergence Delirium (PAED) scale
- Secondary Outcome Measures
Name Time Method Pain score At each two points: during emergence in operating room and 30 minutes after surgery ends Modified Children's Hospital of Eastern Ontario Pain Scale, CHEOPS)
Nausea At each two points: during emergence in operating room and 30 minutes after surgery ends visual analogue scale
Duration of post-anesthetic care unit (PACU) stay During 1 hour after surgery at PACU Duration of post-anesthetic care unit (PACU) stay
vomiting At each two points: during emergence in operating room and 30 minutes after surgery ends number
Trial Locations
- Locations (1)
SNUH
🇰🇷Seoul, Jongro Gu, Korea, Republic of