Multi Center Clinical trial of endovascular treatment of acute ischemic stroke in the Netherlands. - MR CLEA

Erasmus MC Rotterdam0 个研究点开始时间: 2010年6月11日最近更新: 2014年10月7日

适应症

试验速览

暂无简介。

•*A clinical diagnosis of acute stroke, with a deficit on the NIH stroke scale of more than 2 points.
•CT or MRI scan ruling out intracranial hemorrhage.
•Intracranial arterial occlusion of the distal intracranial carotid artery or middle (M1/M2) or anterior (A1/A2) cerebral artery, demonstrated with CTA, MRA, DSA or transcranial Doppler/duplex (TCD).
•The possibility to start treatment within 6 hours from onset.
•Informed consent given.
•Age 18 or over.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 250
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 250

•- cerebral infarction in past 6 weeks
•-history in intracerebral bleeding
•-RR > 185/110 unresponsive to antihypertensive agents
•-blood glucose of < 2.7 or > 22.2
•-Clinical signs of hemorrhagic diathesis or platelet count <90 x 10*9/L, APTT>50 sec or INR >1.7
•- intravenous treatment with thrombolysis with a dose exceeding 0.9mg/kg or 90 mg
•-patients who are treated with intravenous thrombolysis while having cantra-indications for it.
•Exclusion criteria for mechanical thrombectomy
•- carotid artery stenosis over 70% (NASCETT) which cannot be stented
•-RR > 185/110
•-Blood glucose < 2.7 or >22.2
•-INR > 3.0 or platelet count < 40 x 10*9

发起方

Erasmus MC Rotterdam