Mobile Chat Messaging for Alcohol Reduction in Patients With Chronic Liver Diseases

Not Applicable

Active, not recruiting

• Conditions: Chronic Liver Disease
• Interventions: Behavioral: Mobile chat messaging; Behavioral: Screening, brief intervention and referral to treatment

• Registration Number: NCT06587568
• Lead Sponsor: The University of Hong Kong

Brief Summary

The goal of this pilot randomized controlled trial is to evaluate the trial feasibility and acceptability of mobile chat messaging for reducing alcohol use among patients with chronic liver diseases. Specific objectives include:

1. To assess whether the eligibility criteria were too restrictive by estimating the eligibility rate

2. To assess how many eligible CLD patients accepted the invitation to participate in the trial

3. To assess the participant retention rate through 6 months after treatment initiation

4. To assess the intervention acceptability in terms of participants' engagement with and rating of the chat messaging intervention.

5. To assess the safety of the intervention

6. To estimate the intervention effect on alcohol use outcomes and liver functions

7. To synthesise data to inform the sample size calculation in the future definitive trial

8. To explore the participants' perception and experiences in the chat-based intervention

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-09-05
• Study First Submitted QC: 2024-09-05
• Study First Posted: 2024-09-19
• Study Start: 2024-10-02
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-28
• Last Update Posted: 2025-05-01
• Primary Completion: 2025-11-30
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

1. Age ≥18 years
2. Diagnosed with chronic liver disease
3. Alcohol Use Disorders Identification Test score ≥8
4. Own a smartphone with a mobile instant messaging app installed
5. Able to read and communicate in Chinese

Exclusion Criteria

1. Having a psychiatric or psychological disease or on psychotropic drugs
2. Participating in other alcohol reduction or abstinence programmes
3. Require emergency or in-patient treatment after consultation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mobile chat messaging	Mobile chat messaging	Mobile chat messaging + Screening-based alcohol intervention
Mobile chat messaging	Screening, brief intervention and referral to treatment	Mobile chat messaging + Screening-based alcohol intervention
Brief intervention	Screening, brief intervention and referral to treatment	Screening-based alcohol intervention only

Primary Outcome Measures

Name	Time	Method
Recruitment rate	Through recruitment completion, about 8 months	Number of participants divided by the number of eligible subjects
Retention rate	6 months after randomisation	Number of participants completed the follow-up divided by the number of participants
Weekly alcohol consumption	6 months after randomisation	Assessed by questions 1 and 2 of AUDIT-C

Secondary Outcome Measures

Name	Time	Method
Eligibility rate	Through recruitment completion, about 8 months	Number of eligible patients divided by the number of patients screened
Weekly alcohol consumption	3 months after randomisation	Assessed by questions 1 and 2 of AUDIT-C
Frequency of heavy episodic drinking	6 months after randomisation	Assessed by question three of AUDIT-C
AUDIT score and level	6 months after randomisation	Assessed by the Alcohol Use Disorders Identification Test
Total alcohol consumption in the past week	6 months after randomisation
Past 7-day total alcohol consumption	3 months after randomisation	Measured in grams
Past 7-day alcohol abstinence	6 months after randomisation	Self-reported
Past 30-day alcohol abstinence	6 months after randomisation	Self-reported

Trial Locations

Locations (1)

Queen Mary Hospital; 🇭🇰 Hong Kong, Hong Kong