Comparison of continuous versus intermittent phototherapy for treatment of non-hemolytic hyperbilirubinemia in late preterm and term infants

Not Applicable

Conditions: Health Condition 1: null- Hyperbilirubinemia

Registration Number: CTRI/2012/09/002968

Lead Sponsor: All India Institute of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 110

Inclusion Criteria

Babies who were born at a gestation of >= 35 weeks and developed jaundice, with bilirubin cutoffs, requiring phototherapy within first two weeks of life, as per AAP practice parameter guidelines will be included in the study if parents are willing to give informed written consent

Exclusion Criteria

The following babies will be excluded from the study.

1.Babies with hemolytic jaundice â?? Rh, ABO, or minor group incompatibility with DCT positive or other hemolytic conditions like G6PD deficiency or peripheral smear showing hemolysis.

2.Total serum bilirubin levels 20 mg/dl

3.Sepsis (symptomatic screen positive/ culture positive)

4.Babies who have received prior phototherapy

5.Babies with hydrops fetalis or major congenital malformations.

6.Non availability of dedicated phototheraphy unit at the time of assessment for eligibility.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the rate of fall of bilirubin defined as difference between total serum bilirubin (TSB) at onset and at termination of phototherapy divided by duration of phototherapy, in continuous vs. intermittent phototherapy. <br/ ><br> <br/ ><br>Timepoint: To determine the rate of fall of bilirubin defined as difference between total serum bilirubin (TSB) at onset and at termination of phototherapy divided by duration of phototherapy, in continuous vs. intermittent phototherapy. <br/ ><br> <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
To compare the efficacy of continuous vs intermittent in the management of non hemolytic hyperbilirubinemia in term and late preterm neonates in terms of <br/ ><br>1.Duration of phototherapy (PT) in hours. <br/ ><br>2.Failure of phototherapy and need for exchange transfusion. <br/ ><br>3.Need for phototherapy for rebound increase in bilirubin <br/ ><br>4.Incidence of hyperthermia 38Â°C <br/ ><br>5.Maternal perception of satisfaction of care and feeding <br/ ><br>6.Breast feeding assessment at discharge <br/ ><br> <br/ ><br>Timepoint: Ongoing monitoring till discharge