Comparison of the Application in Traumatic Brain Edema Between Electrical Impedance Tomography and Non-invasive Intracranial Pressure Monitoring
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Electrical Impedance;
- Sponsor
- Xijing Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- brain electrical impedance
- Last Updated
- 12 years ago
Overview
Brief Summary
Brain edema is the main reason for the disability and lethality in traumatic brain injury, which is the most difficult part of emergency rescue. Recently, there is no medical equipment to monitor the early brain edema in clinic. We have found that Electrical impedance tomography (EIT) can perform the real-time and bedside monitoring of brain electrical impedance after single-dose mannitol treatment, which may be a new strategy for the surveillance of brain edema. In this study, we would like to compare the application in traumatic brain edema between EIT and Noninvasive intracranial pressure (ICP) monitoring, including the progress of brain edema, the relationship between impedance and ICP, and the improvement for the patients' prognosis. EIT would probably be a new image strategy for the treatment of traumatic brain injury.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Eligible patients were 16 to 65 years of age with all genders.
- •The patients had been diagnosed as traumatic brain injury during 24 hours before enrollment, with the confirmation of CT or MRI.
- •All the patients had provided written informed consent.
- •The patients were receiving usual inpatient rehabilitation and conservative treatment .
Exclusion Criteria
- •The patients with indication of operation during the research should be excluded.
- •The patients were assessed as unqualified for the study according to the comprehensive evaluation opinion brought forward by the research team.
Outcomes
Primary Outcomes
brain electrical impedance
Time Frame: From the 1st day (enrollment) to the 7th day
After the patients' enrollment, the electrodes would be placed properly and the continuous monitoring of brain impedance just be started.
Secondary Outcomes
- Glasgow coma scale(GCS)(on the 0 day of the study)
- demographic characteristics at baseline(on the 0 day of the study)
- kidney function examination(On the 1st day, 3rd day, 5th and 7th day)
- Physiological and pathological reflex check(on the 1st and 7th day)
- muscular strength and tension test(on the 1st and 7th day)
- non-invasive intracranial pressure(From the 1st day (enrollment) to the 7th day)
- brain CT scan(On the 1st day (enrollment), and 7th day)
- Disability Rating Scale (DRS)(on the 1st day (enrollment), seventh day after hospitalization)
- glasgow outcome scale(GOS)(the patients were discharged or the 7th day after hospitalization)