Oral Contraceptive and Strength Training

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: oral contraceptive and training; Other: no oral contraceptive and training

• Registration Number: NCT03374878
• Lead Sponsor: University of Aarhus

Brief Summary

Cross sectional study investigating the effect of strength training in users and non-users of oral contraceptives (OC) (2nd generation OC)

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-12-05
• Study First Submitted QC: 2017-12-11
• Study First Posted: 2017-12-15
• Study Start: 2018-02-01
• Status Verified: 2018-06
• Primary Completion: 2019-01-01
• Study Completion: 2019-01-01
• Last Update Submitted: 2019-09-24
• Last Update Posted: 2019-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 38

Inclusion Criteria

• 18.5 - 30 years
• BMI < 30

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Exclusion Criteria

• Medicine influencing protein turnover
• Surgery on the knee
• Arthritis
• Diabetes
• Smoking
• irregular menstruation (<24 days or >35 days cycles)
• Non-users: not have used contraceptives for the last 3 months.
• Unstable weight (+/- 5 kg within the last 6 months)
• Regular training/exercise more than 2 hours/week for the last 6 months. Maximum 70 km of cycling transport/week.
• Strength training >1time/month for the last 6 months.
• Pregnancy
• Diet og eating disorder
• Can not read or understand danish

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oral contraceptive and training	oral contraceptive and training	Users of oral contraceptive training for 10 weeks
no oral contraceptive and training	no oral contraceptive and training	Non-users of oral contraceptive training for 10 weeks

Primary Outcome Measures

Name	Time	Method
Muscle mass	Baseline + after 10 weeks of resistance training.	Change in muscle mass determined by MRI scan of thigh muscle

Secondary Outcome Measures

Name	Time	Method
Muscle fiber size	Baseline + after 10 weeks of resistance training.	Change in muscle fiber cross sectional area measured by histology.
Functionality	Baseline + after 10 weeks of resistance training.	Change in jump performance by RSI (Reactive strength index) measures
Blood values	Baseline + after 10 weeks of resistance training.	Change in sex hormone profile measured by blood sample analysis
Fat free mass (FFM)	Baseline + after 10 weeks of resistance training.	Change in FFM measured by dual energy x-ray absorptiometry (DXA) scan of whole body composition
Muscle strength	Baseline + after 10 weeks of resistance training.	Change in isometric strength

Trial Locations

Locations (1)

Aarhus University, Department for Public Health, Section for Sport Science; 🇩🇰 Aarhus, Denmark