The Influence of Oral Contraceptive Use on Muscle Recovery

Not Applicable

Completed

• Conditions: Recovery; Oral Contraceptive Use
• Interventions: Procedure: Training

• Registration Number: NCT04564300
• Lead Sponsor: University of Aarhus

Brief Summary

There is still no one who has studied how oral contraceptive use affects recovery in trained women after repeated high-intensity workouts. Consequently, a well-controlled study is needed.

The project is designed as a controlled cohort study, where 20 oral contraceptive users will be compared with 20 non-users. After initial preliminary examination and habituation to the test procedures, the subjects will start the intervention in week 2 of their menstrual cycle / active contraceptive pill cycle. Before and 3h, 24h and 48h after 3 intense strength training sessions performed 2 days in a row, blood samples will be taken, muscle soreness measured and performance tests performed. The day before the first training session and over the 4 trial days, the subjects will receive a standardized diet.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2020-09-21
• Study First Submitted QC: 2020-09-21
• Study First Posted: 2020-09-25
• Study Start: 2020-10-19
• Primary Completion: 2022-09-27
• Study Completion: 2023-09-27
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-08
• Last Update Posted: 2024-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• BMI 18.5-30
• Regular training minimum. 4 times a week (1≤ times strength training, 1≤ times endurance training / interval training or interval-based sports. If the interest in participation is greater than necessary, we will prioritize people who perform strength training at least twice a week)

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Exclusion Criteria

• Irregular menstruation over the last 6 months (shorter than 24 days or longer than 35 days cycle)
• Used birth control pills for less than 6 months
• Non-birth control pill users must not have used birth control pills, IUDs, birth control pills, or mini- pills for a maximum of 1 month during the last 6 months and not within the last 3 months up to the trial. .
• Injuries / pain in the lower body, which prevents participation in intense strength training
• Medication consumption that may affect protein metabolism and inflammatory parameters.
• Diabetes
• Smoking
• Unstable weight / major weight loss (weight fluctuations of more than 5 kg in the last six months)
• Eating disorder
• Pregnancy
• Cannot read or understand Danish

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Non-oral contraceptive users	Training	-
Oral contraceptive users	Training	-

Primary Outcome Measures

Name	Time	Method
Changes in maximal knee extensor strength and Rate of force development	Before, 3 hours , 24 hours and 48 hours after training	Measured in a Humac Norm dynamometer

Secondary Outcome Measures

Name	Time	Method
Changes in Wingate performance	Before, 3 hours , 24 hours and 48 hours after training.	Peak power and average power
Changes in Yoyo-intermittent recovery 1 performance	Before, and 48 hours after training.	total length covered in the yo-yo test
Changes training volume	Before, 3 hours , 24 hours and 48 hours after training.	total volume performed during training (i.e set x reps x working weight)
Changes in Jumping performance	Before, 3 hours , 24 hours and 48 hours after training.	leg stiffness
Differences in knee laxity	Baseline	Measured with a Lachmeter
Changes in Leg press performance	Before, 3 hours , 24 hours and 48 hours after training.	Total reps performed at 80% of 1RM
Changes in muscle soreness (VAS-score)	Before, 3 hours , 24 hours and 48 hours after training	Subjects will raise and sit on a chair and immediately after answer a VAS-score (100mm line, from worst pain ever, to no pain at all.)
Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage	Before, 3 hours , 24 hours and 48 hours after training	IL-6

Trial Locations

Locations (1)

Aarhus University, Department for Public Health, Section for Sport Science; 🇩🇰 Aarhus, Denmark