Consequences of suboptimal glucocorticoid replacement therapy in Addison’s disease; The metabolic syndrome and QoL.
- Conditions
- Addison's disease, metabolic syndrome, quality of life, glucocorticoid receptor polymorphisms
- Registration Number
- NL-OMON22793
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Patients with primary adrenal insufficiency in the age of 18-70 years.
Exclusion Criteria
1. Intercurrent infectious or serious disease;
2. Use of other oral medications containing glucocorticoids;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Presence of metabolic syndrome (3 or more abnormalities of waist circumference, blood pressure, triglycerides, HDL-cholesterol, glucose);<br /> <br>2. Quality of life score.<br>
- Secondary Outcome Measures
Name Time Method Presence of glucocorticoid receptor polymorfisms in relation to the metabolic syndrome and QoL.