Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes

Completed

• Conditions: Healthy

• Registration Number: NCT00726778
• Lead Sponsor: University of Alabama at Birmingham

Brief Summary

The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in aspects of insulin secretion and action. The genetic component will be modeled by estimating the degree of European genetic admixture (ADM) obtained from approximately 50 ancestry informative markers (AIMs). The environmental components will be modeled by measuring energy intake (food intake), energy expenditure (physical activity) and socioeconomic status.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-05
• Study First Submitted: 2008-07-29
• Study First Submitted QC: 2008-07-31
• Study First Posted: 2008-08-01
• Primary Completion: 2008-12
• Study Completion: 2010-12
• Status Verified: 2011-03
• Last Update Submitted: 2011-03-15
• Last Update Posted: 2011-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 360

Inclusion Criteria

• African American, European American, or Hispanic American, aged 7-12, healthy, weight is equal to or greater than 25 Kg

Exclusion Criteria

• Type 1 or 2 diabetes, polycystic ovary disease, disturbances in glucose or lipid metabolism disturbances
• Use of medication known to affect body composition or physical activity, diagnosis of genetic disorders known to affect body composition or fat distribution
• Use of tobacco, alcohol consumption in excess of 400 g per week
• Menstruated for more than a year prior to the recruitment; OR
• A medical history that counter-indicates inclusion of the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To test the role of European genetic admixture on measures of insulin action and response in a multiethnic group of prepubertal children.	5 years
To investigate whether the impact of energy intake, energy expenditure and socioeconomic status on proxy measures of insulin sensitivity and/or action differ as a function of European ADM in prepubertal children	5 years
To test phenotype-genotype associations between each one of the AIMs and measures of FI, SI and AIRg after adjusting for body composition in a sample of AA, HA and EA prepubertal children.	5 years

Trial Locations

Locations (1)

University of Alabama at Birmingham; 🇺🇸 Birmingham, Alabama, United States