Assessing Insulin Sensitivity and Diabetes Risk in Childhood Cancer Survivors Treated With Abdominal Irradiation
Completed
- Conditions
- Childhood Cancer Survivors Treated With Abdominal Radiation
- Registration Number
- NCT02248779
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Brief Summary
The purpose of this study is to better understand the risk factors and causes of diabetes in people who received radiation to the abdomen as children. The investigators hope this information will allow them to improve how they screen people at risk for diabetes and how they treat patients in the future.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
- Diagnosis of childhood cancer between 0-21 years of age
- Prior treatment with abdominal radiation at MSKCC
- Two or more years from completion of therapy
- Records of cancer diagnosis and treatment (including radiation records) available
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Exclusion Criteria
- Known diagnosis of diabetes
- Previous treatment with any radiation impacting the brain (cranial radiation, craniospinal radiation, total body irradiation)
- Neurocognitive deficits that impair ability to give informed consent or assent
- Patients predicted to have difficult intravenous access, who will likely require multiple venipuncture attempts
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method characterize β cell function 2 years we will be able to estimate the proportion of patients with abnormalities of insulin sensitivity or β cell function, as assessed by the OGTT, to within ± 0.14.
insulin sensitivity 2 years we will be able to estimate the proportion of patients with abnormalities of insulin sensitivity or β cell function, as assessed by the OGTT, to within ± 0.14.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States