Near Infrared Spectroscopy (NIRS) to Measure Tissue Oxygen Saturation (St02)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 186
- 试验地点
- 1
- 主要终点
- Organ Dysfunction and Severity of Illness
研究概览
简要总结
The overall hypotheses of this project is that Near Infrared Spectroscopy (NIRS) can be used to identify morbidity, mortality, and resource utilization in patients with sepsis and septic shock.
详细描述
Near-infrared spectroscopy (NIRS) noninvasively measures peripheral tissue oxygen saturation (StO2), offering promise as a guide in the early treatment of severe sepsis; however, the role and utility of this technology is still evolving.
There are three main NIRS measurements reported in the literature: continuous StO2 measurement (StO2 initial), StO2 occlusion slope (StO2 downslope) in response to VOT testing and StO2 recovery slope (StO2 upslope) in response to vasoocclusive testing. The purpose of this study is to assesses the association of each of these parameters with severity of illness, organ dysfunction and death.
This study will utilize the Hutchinson InSpectra StO2 tissue oxygenation monitor, which is FDA approved for use in monitoring patients during circulatory or perfusion examinations of skeletal muscle, or when there is a suspicion of compromised circulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Listed on the Cohorts description.
排除标准
- •All patient cohorts will share common set of exclusion criteria:
- •Age < 18 years
- •Pregnancy
- •Established "Do Not Resuscitate" orders prior to enrollment
- •Primary diagnosis of:
- •Acute traumatic or burn injury
- •Acute cerebrovascular event
- •Acute coronary syndrome
- •Acute pulmonary edema
- •Cardiac dysrhythmia
- •Acute and active gastrointestinal bleeding
- •Acute drug overdose
- •Requirement for immediate surgery
- •Inability to obtain written informed consent
结局指标
主要结局
Organ Dysfunction and Severity of Illness
时间窗: time 0 - 24 hrs
次要结局
- Mortality(In hospital)
研究者
Nathan Shapiro
Associate Professor of Medicine
Beth Israel Deaconess Medical Center