The project intends to look for biological markers in the urine and blood that can detect kidney injury in the transplanted kidney in patients undergone kidney transplantation surgery
Not Applicable
- Conditions
- Health Condition 1: N185- Chronic kidney disease, stage 5
- Registration Number
- CTRI/2019/10/021519
- Lead Sponsor
- Intra Mural Grant from All India Institute of Medical Sciences New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients must be aged above 18
2. Patients willing to participate in the study
3. Immunologic higher risks (PRA > 20%, HLA mismatches >= 1).
4. Cross match negative
Exclusion Criteria
1. Patients who do not provide consent for the study
2. Age group <18 years.
3. Non-renal allograft patients
4. No Urine output
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the pattern of blood and urine biomarker (FOXP3, OX40, PD1 and TIM3) excretion among post renal allograft patients at different time pointTimepoint: 0 day <br/ ><br>5th day <br/ ><br>9th day <br/ ><br>14th day
- Secondary Outcome Measures
Name Time Method To correlate the biomarker expression with biopsy proven acute kidney allograft injury (acute allograft rejection or acute tubular necrosis or calcineurin-inhibitor nephrotoxicity) during post transplantation surgeryTimepoint: 0 day <br/ ><br>5th day <br/ ><br>9th day <br/ ><br>14th day