EUCTR2005-003997-74-DK
Active, not recruiting
Phase 1
Depletion of regulatory T-lymphocytes by intratumoral injection of antibodies.
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Rigshospitalet
- Enrollment
- 30
- Status
- Active, not recruiting
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histopathologically verified cancer with metastasis. No further conventional anti\-cancer treatment options.
- •Radiological visualisation of cancer/metastasis localisation must enable direct or ultrasonography mediated intratumoral injection
- •Cancer diseases preferred:
- •1\. liver, primary and secondary.
- •2\. mammary cancer
- •3\. sarcomas
- •4\. melanomas
- •5\. prostate
- •6\. kidney, hypernefroma
- •Are the trial subjects under 18? yes
Exclusion Criteria
- •Expected lifetime \< 3 months
- •ECOG 3\-4\.
- •Ongoing infection
- •\< 4 weeks from prior immunosuppressive therapy
- •Billirubin \>2 times upper normal value
- •ASAT/ALAT \>2 times upper normal value
- •abnormal creatinine
- •\< 4 weeks from major surgery
- •positive pregnancy test
- •No use of safe barrier contraception
Outcomes
Primary Outcomes
Not specified
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