Cerebrovascular Response to Acute Exercise

Not Applicable

Completed

• Conditions: Physical Activity; Healthy
• Interventions: Other: Control; Other: Aerobic Exercise

• Registration Number: NCT03722953
• Lead Sponsor: University of Wisconsin, Madison

Brief Summary

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Detailed Description

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function

2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.

3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Study Timeline

• Study First Submitted: 2018-10-15
• Study First Submitted QC: 2018-10-25
• Study First Posted: 2018-10-29
• Study Start: 2018-12-01
• Primary Completion: 2020-03-09
• Study Completion: 2020-03-09
• Status Verified: 2022-06
• Last Update Submitted: 2024-09-30
• Last Update Posted: 2024-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Between 20-40 years old
• BMI < 30 kg/m2
• Recreationally active
• Experience running on a treadmill

Exclusion Criteria

• Current smoker
• History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
• Taking blood pressure medication
• History of depression or other mood related disorders
• Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Aerobic Exercise	Control	Control: Cerebrovascular function and peripheral vascular function will be measured. Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.
Aerobic Exercise	Aerobic Exercise	Control: Cerebrovascular function and peripheral vascular function will be measured. Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.

Primary Outcome Measures

Name	Time	Method
Cerebrovascular function	Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.	Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test
Peripheral vascular function	Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.	Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia

Trial Locations

Locations (1)

Gymnasium-Natatorium; 🇺🇸 Madison, Wisconsin, United States