Prevention of acute kidney injury by cardiopulmonary bypass: role of haptoglobin administration for hemolysis

Not Applicable

Recruiting

• Conditions: Valvular heart disease; Hemolysis, cardiopulmonary bypass, operation; D006349, D001014, D000784

• Registration Number: JPRN-jRCT1031190038
• Lead Sponsor: agasaka Yasuko

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-06-11
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 336

Inclusion Criteria

1) Patients aged >=20 years
2) Patients undergoing heart surgeries under artificial heart-lung machine for a long period of time at Tokyo Women's Medical University Hospital (Definition of long period of time: 2 hours or more)
3) Patients who have written consent to participate in this study

Exclusion Criteria

1) Dialysis patients, after kidney transplantation, on
e kidney
2) Congenital kidney disease
3) Emergency surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The occurrence of acute kidney failure is evaluated using the KDIGO classification Stage 1.

Secondary Outcome Measures

Name	Time	Method
Hemodialysis<br>Stage 3 in the AKI diagnostic criteria according to the KDIGO guidelines<br>Time from entering the ICU to extubation, and ICU stay time<br>Death during hospitalization or 30 days after surgery<br>MAKE 1, 3 and 5 years