CARdiac Disfunction In Obesity * Early Signs Evaluatio
Completed
- Conditions
- cardiac dysfunction in obesityreduced function of the heart in overweight1001928010018424
- Registration Number
- NL-OMON43357
- Lead Sponsor
- Sint Franciscus Gasthuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Obesity patients undergoing bariatric surgery:
BMI * 35 kg/m2, age 18-65 year and informed consent;Healthy controles:
Age 18-65 years and written informed consent
Exclusion Criteria
Obesity patients undergoing bariatric surgery:
Known cardiovascular disease.;Healthy controles:
BMI of * 30 kg/m2, known cardiovascular disease.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary Objective:<br /><br>To quantify the proportion of early signs of cardiac dysfunction in obese<br /><br>patients scheduled for bariatric surgery; To determine if obese patients<br /><br>scheduled for bariatric surgery have an elevated risk of (early signs of)<br /><br>cardiac dysfunction.<br /><br><br /><br>This objective will be studied by comparing parameters of cardiac dysfunction<br /><br>in obesity patients (before bariatric surgery) with age and gender matched<br /><br>healthy controls.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary Objective:<br /><br>To gain insight in the pathophysiology of obesity causing cardiac dysfunction .<br /><br><br /><br>This objective will be studied by:<br /><br>1. relating signs of cardiac dysfunction to specific features of obesity<br /><br>[inflammation, lipids, diabetes, etc.]<br /><br>2. relating changes from before to one year after bariatric surgery in cardiac<br /><br>dysfunction and metabolic state to each other), in a longitudinal cohort study,<br /><br>comparing parameters of cardiac dysfunction in obesity patients before vs. 1<br /><br>year after bariatric surgery, as well as the parameters associated with a<br /><br>change of cardiac dysfunction parameters.</p><br>