Biomarker in Tumor Tissue Samples From Patients With Rhabdomyosarcoma
- Conditions
- Sarcoma
- Registration Number
- NCT01365962
- Lead Sponsor
- Children's Oncology Group
- Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in tumor tissue samples from patients with rhabdomyosarcoma.
- Detailed Description
OBJECTIVES:
* To determine and quantify the degree of surface insulin-like growth factor I receptor (IGF-IR) expression in rhabdomyosarcoma (RMS) tumor tissue.
* To assess the feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue.
OUTLINE: Paraffin-embedded tumor tissue slides are analyzed for insulin-like growth factor I receptor (IGF-1R) expression by mass spectrometry and correlated with the results obtained by IHC assay.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Degree of surface IGF-IR expression in RMS tumor tissue Feasibility and validity of a mass spectrometry assay for IGF-IR expression on paraffin-embedded tumor tissue
- Secondary Outcome Measures
Name Time Method