Neural Correlates of Real World Spatial Navigation in Humans

Not Applicable

Recruiting

• Conditions: Memory, Delayed

• Registration Number: NCT04874220
• Lead Sponsor: University of California, Los Angeles

Brief Summary

The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-30
• Study First Submitted: 2021-04-28
• Study First Submitted QC: 2021-04-30
• Study First Posted: 2021-05-05
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-24
• Last Update Posted: 2024-04-26
• Primary Completion: 2025-06-30
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• 18 years of age or older and has undergone RNS system placement
• Willing to provide informed consent and participate the study
• Ability to read and write English fluently

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Exclusion Criteria

• Unwilling to provide informed consent
• Not a native English Speaker

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Oscillatory activity change	Throughout study completion, an average of 2-4 days per year	Changes in theta, gamma, and theta-gamma coupling will be measured both in relation to changes in memory performance on trials with and without deep brain stimulation as well as in relation to body, head, and eye position in a virtual, augmented, or real-world environment.
Spatial memory	Throughout study completion, an average of 2-4 days per year	Spatial memory will be measured using virtual, augmented and real-world spatial navigation tasks where participants will be asked to navigate a previously learned rout as well as if they recognize objects (i.e. landmarks) that appeared along the route (photos of seen landmarks vs unseen landmarks).
Memory performance change	Throughout study completion, an average of 2-4 days per year	Memory performance will be measured using excess path length, latency, and accuracy rate.

Trial Locations

Locations (1)

University of California Los Angeles; 🇺🇸 Los Angeles, California, United States