The prevalence of mutations in the MC4R, POMC and LEPR genes in Thai patients with morbid obesity receiving bariatric surgery and bariatric surgery outcome

Recruiting

• Conditions: Monogenic obesityBariatric surgery; Obesity; Bariatric surgery; Obesity genetics; MC4R; POMC; LEPR; Remission of diabetes

• Registration Number: TCTR20221109004
• Lead Sponsor: Ratchadapisek Somphot Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-09
• Study Completion: 2023-12-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1.Morbid obesity who underwent bariatric surgery
2.Age between 18 and 65 years

Exclusion Criteria

1.Syndromic forms of obesity
2.Obesity due to endocrine disorders
3.Obesity due to hypothalamic disorders
4.Pregnancy and lactation
5.Weight loss lowering medications after surgery

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of mutations Time at enrollment Sanger sequencing

Secondary Outcome Measures

Name	Time	Method
Percentage of total weight loss Body weight after surgery at 3, 6, 12, 18 months and then yearly Body weight