Hereditary Colorectal and Associated Tumor Registry Study

University of Pittsburgh1 site in 1 country114 target enrollmentApril 2012

ConditionsLynch Syndrome FAP Hereditary Diffuse Gastric Cancer Juvenile Polyposis Syndrome Peutz-Jeghers Syndrome

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Lynch Syndrome
Sponsor: University of Pittsburgh
Enrollment: 114
Locations: 1
Primary Endpoint: Establish a Hereditary Colorectal Tumor Registry to facilitate development and implementation of epidemiological, clinical and cancer control research.
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.

Registry

clinicaltrials.gov

Start Date

April 2012

End Date

January 26, 2018

Last Updated

8 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Pittsburgh

Responsible Party

Principal Investigator

Randall Brand

Principal Investigator

University of Pittsburgh

Eligibility Criteria

Inclusion Criteria

•Identified gene mutation
•Personal history of colorectal cancer diagnosed ≤ 50
•Personal history of cancer with tumor studies suggestive of Lynch syndrome
•Personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain)
•Personal history of one of the above cancers and a family history of one or more of the above cancers
•Personal or family history of diffuse gastric cancer
•From a known genetic predisposition family
•Personal history of \> 10 colon adenomas (cumulative over a lifetime)
•Personal history of any number of hamartomatous polyps
•Personal history of multiple large (\> 1cm) serrated polyps to right of sigmoid

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Establish a Hereditary Colorectal Tumor Registry to facilitate development and implementation of epidemiological, clinical and cancer control research.

Time Frame: 1-N/A (up to 8 years)