Hereditary Colorectal and Associated Tumor Registry Study

Completed

• Conditions: Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome; Hereditary Diffuse Gastric Cancer; FAP; Lynch Syndrome

• Registration Number: NCT00633607
• Lead Sponsor: University of Pittsburgh

Brief Summary

After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study First Submitted: 2008-03-03
• Study First Submitted QC: 2008-03-11
• Study First Posted: 2008-03-12
• Study Start: 2012-04
• Primary Completion: 2018-01-26
• Study Completion: 2018-01-26
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-15
• Last Update Posted: 2018-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 114

Inclusion Criteria

• Identified gene mutation
• Personal history of colorectal cancer diagnosed ≤ 50
• Personal history of cancer with tumor studies suggestive of Lynch syndrome
• Personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain)
• Personal history of one of the above cancers and a family history of one or more of the above cancers
• Personal or family history of diffuse gastric cancer
• From a known genetic predisposition family
• Personal history of > 10 colon adenomas (cumulative over a lifetime)
• Personal history of any number of hamartomatous polyps
• Personal history of multiple large (> 1cm) serrated polyps to right of sigmoid

Exclusion critera:

• Individuals under the age of 8
• Individuals who cannot travel to Pittsburgh for in-person enrollment
• Individuals who cannot provide informed consent

Read More

Exclusion Criteria

Not provided

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Establish a Hereditary Colorectal Tumor Registry to facilitate development and implementation of epidemiological, clinical and cancer control research.	1-N/A (up to 8 years)

Trial Locations

Locations (1)

University of Pittsburgh; 🇺🇸 Pittsburgh, Pennsylvania, United States