Serum Cytokine Levels in Patients with Lumbal Disc Herniation with and Without Neurological Deficits and Effectiveness of Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 111
- 试验地点
- 2
- 主要终点
- inflammatory cytokines
研究概览
简要总结
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study.
详细描述
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study. Healthy individuals of similar age, height and weight will also be included for references to normal serum cytokine levels. All patients will be evaluated twice, before and 6 weeks after treatment. The treatment program will be applied 3 times a week for 6 weeks under the supervision of a physiotherapist.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •systemic or inflammatory disease
- •pregnant or breastfeeding women
- •surgery of lumbar region
- •fracture of lumbar vertebrae
- •lumbar scoliosis
- •medication use for psychiatric disorders
- •neurological disease
- •alcohol-drug use
- •generalized musculoskeletal pain
研究组 & 干预措施
The general exercise group
The general exercise group will perform conventional exercises 3 times a week during 6 weeks.
干预措施: Conventional exercises (Other)
The stabilization group
The stabilization group will perform lumbal stabilization exercises in lying, sitting, standing and on a swisball 3 times a week during 6 weeks.
干预措施: Lumbal stabilization excercises (Other)
The control group
Individuals in the control group will not be treated.
结局指标
主要结局
inflammatory cytokines
时间窗: 6 weeks
Tnf-alfa , IL-6, IL-4, IL-1β, Beta-endorphins, Anandamide, Arachidonoylgylycerol will be evaluated with ELISA kit.
次要结局
未报告次要终点
研究者
birgül morkoç
Principal investigator
Hacettepe University