Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise

Not Applicable

Completed

• Conditions: Low Back Pain
• Interventions: Other: Lumbal stabilization excercises; Other: Conventional exercises

• Registration Number: NCT04912388
• Lead Sponsor: Hacettepe University

Brief Summary

The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study.

Detailed Description

The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits. Patients who applied to Hacettepe University Hospitals Physical Medicine and Rehabilitation Department with low back pain complaints and were referred for treatment will be included in the study. Healthy individuals of similar age, height and weight will also be included for references to normal serum cytokine levels. All patients will be evaluated twice, before and 6 weeks after treatment. The treatment program will be applied 3 times a week for 6 weeks under the supervision of a physiotherapist.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-05-28
• Study First Submitted QC: 2021-05-28
• Study First Posted: 2021-06-03
• Study Start: 2021-07-30
• Primary Completion: 2024-02-23
• Status Verified: 2024-03
• Study Completion: 2024-07-30
• Last Update Submitted: 2024-10-01
• Last Update Posted: 2024-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 111

Inclusion Criteria

Not provided

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Exclusion Criteria

• systemic or inflammatory disease
• pregnant or breastfeeding women
• surgery of lumbar region
• fracture of lumbar vertebrae
• lumbar scoliosis
• medication use for psychiatric disorders
• tumor
• allergy
• neurological disease
• alcohol-drug use
• generalized musculoskeletal pain

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
The stabilization group	Lumbal stabilization excercises	The stabilization group will perform lumbal stabilization exercises in lying, sitting, standing and on a swisball 3 times a week during 6 weeks.
The general exercise group	Conventional exercises	The general exercise group will perform conventional exercises 3 times a week during 6 weeks.

Primary Outcome Measures

Name	Time	Method
inflammatory cytokines	6 weeks	Tnf-alfa , IL-6, IL-4, IL-1β, Beta-endorphins, Anandamide, Arachidonoylgylycerol will be evaluated with ELISA kit.

Trial Locations

Locations (1)

Faculty of Physiotherapy and rehabilitation; 🇹🇷 Ankara, Altındağ, Turkey