A prospective genetic study of patients with bilateral Wilms tumor for preparation of genetic counseling (RTBL14GP2)

Not Applicable

• Conditions: Bilateral Wilms tumor

• Registration Number: JPRN-UMIN000025155
• Lead Sponsor: Renal Tumor Committee, Japan Childrens Cancer Group

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-12-06
• Study Completion: 2019-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

Not provided

Exclusion Criteria

Patients not to register to Multi-center clinical trial for Japanese children with bilateral nephroblastoma (RTBL14)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify various germinal mutations and the incidence of each germinal mutation, that caused bilateral Wilms tumor.

Secondary Outcome Measures

Name	Time	Method
1) To clarify that the germinal mutations identified in patients with bilateral Wilms tumor are inherited from their parents or occurred de novo. 2) To identify germinal mutations in blood from families and to clarify the association between the mutation and their past history of Wilms tumor in order to determine the penetrance rates of bilateral Wilms tumor.