The influence of high frequency 10Hz repetitive transcranial magnetic stimulation (rTMS) on experimental pain measured through quantitative sensory testing in healthy subjects.
Phase 2
- Conditions
- Pijn, Centraal Zenuwstelsel: Verwerking van pijn.Pain
- Registration Number
- NL-OMON43483
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Subject is or is older than 18 years.
2. Subjects should be naïve to rTMS treatment
Exclusion Criteria
1. Subject has an condition with risk of magnetic interference while using rTMS.
2. Subject has an condition with increased or uncertain risk of inducing epileptic seizures while using rTMS(active or history of epilepsy, lesions of the brain, interfering drugs/medication)
3. Subject has an conditions with increased risk of other events while using rTMS (pregnancy, severe hearth disease)
3. Subject has an history of, clinical signs/symptoms of, or concomitant acute or chronic pain.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Analgesic effect is measured through QST. QST measurements will be performed<br /><br>using different modalities, e.g. mechanical pressure, electrical stimulation<br /><br>and conditioned pain modulation (CPM). The primary outcome is pressure pain<br /><br>threshold (PPT).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes are: Electric Sensation Threshold in mA, Electric Pain<br /><br>Threshold in mA, Electric Pain Tolerance Threshold in mA, Conditioned Pain<br /><br>Modulation Paradigm in kPa for PPT and mA for EPPT and VAS-score (0-10). Mask<br /><br>validity tests in % (for both rTMS and sham).<br /><br>And Adverse events.</p><br>