Effect of vitamin D supplement on muscle function, metabolic markers and quality of life in post I-131 hypothyroid patients
Phase 4
Recruiting
- Conditions
- vitamin D supplement on muscle function in hypothyroid patientsvitamin D supplement on metabolic markers in hypothyroid patientsvitamin D supplement on quality of life in hypothyroid patientsvitamin Dhypothyroidismmuscle functionmetabolic markersquality of life
- Registration Number
- TCTR20230107005
- Lead Sponsor
- Faculty of Medicine, Chiang Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Patients with I-131 induced hypothyroidism and currently receiving thyroid hormone therapy with normal thyroid hormone levels and stable thyroid hormone replacement doses for at least 6 months
2. 18 to 70 years of age
Exclusion Criteria
1. Patients with thyroid cancer
2. Patients with underlying disease such as cerebrovascular disease, chronic kidney failure(eGFR < 60 ml/min/1.73m2), diabetes mellitus, muscle disease, major depressive disorder, cancer, liver cirrhosis (Child-Pugh class B,C) , and malabsorption
3. Patients with abnormal calcium and phosphate levels
4. Pregnant patient
5. Patient who was already receiving vitamin D and calcium supplements
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hand grip before the study, in the 3rd month, and in the 6th month Jamar handgrip dynamometer,5 times chair stand test before the study, in the 3rd month, and in the 6th month Time used(sec)
- Secondary Outcome Measures
Name Time Method ean body mass(kg) before the study, in the 3rd month, and in the 6th month Tanita BC-545 N body composition analyzer ,Fat mass(kg) before the study, in the 3rd month, and in the 6th month Tanita BC-545 N body composition analyzer,Insulin resistance before the study, in the 3rd month, and in the 6th month By using HOMA-IR,Quality of life before the study, in the 3rd month, and in the 6th month By answering questionnaires SF-36