Vitamin D supplementation and muscle strength in sarcopenic and obese sarcopenic elderly Lebanese people

Completed

• Conditions: Vitamin D deficiency; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN10618249
• Lead Sponsor: Hôpital St. Charles

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-06
• Last Update Posted: 21 August 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

1. Deficient in vitamin D
2. Age 70 years and over
3. No medical history of type 2 diabetes, congestive heart failure, renal failure or acute heart insufficiency

Exclusion Criteria

1. Not deficient in vitamin D
2. Under 70 years of age
3. Having a medical history of type 2 diabetes, congestive heart failure, renal failure or acute heart insufficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All primary outcomes are assessed at baseline and after 6 months of intervention.<br>1. Vitamin D (25(OH)D) is measured by radioimmunoassay (DiaSorin, Stillwater, MN)<br>2. Handgrip strength is measured in the dominant hand with a Martin vigorimeter (Martin; Elmed, Addison, IL, USA), and the force was expressed in kilograms (kg)<br>3. Skeletal muscle mass is anticipated from bioimpedance analysis measurements (Tanita BC-418 Segmental Body Composition Analyzer, Illinois, USA) and expressed as appendicular skeletal muscle mass (ASMM, kg)<br>4. Total lean body mass is measured using Tanita BC-418 Segmental Body Composition Analyzer, Illinois, USA<br>5. Fat mass is measured using Tanita BC-418 Segmental Body Composition Analyzer, Illinois, USA<br>6. Parathyroid hormone is measured using a two-site immunoradiometric assay with an NH2-terminal monoclonal antibody as capture (Fitzgerald Industries International Inc., USA)

Secondary Outcome Measures

Name	Time	Method
All secondary outcomes are assessed at baseline and after 6 months of intervention.<br>1. Weight (kg) is assessed using the body composition analyzer (Tanita BC-418 Segmental Body Composition Analyzer, Illinois,USA)<br>2. Body mass index (BMI) is calculated using the standard formula (body weight in kilograms divided by the square of the body height in meters [kg/m²])<br>3. Serum creatinine is measured using the Jaffe rate method, the kinetic alkaline picrate (Interpretation and Techniques, Lea and Febiger, Philadelphia)