CARDIAC EFFECTS OF HIGH THORACIC EPIDURAL ANAESTHESIA DURING BICYCLE EXERCISE: AN ECHOCARDIOGRAPHIC STUDY

Completed

Conditions: invloed van sympathicusblokkade door HTEA op de functie van het hart tijdens inspanning
cardiac function
epidural anesthesia

Registration Number: NL-OMON40956

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

Patients younger than 65 years
ASA 1 or 2 patients undergoing thoracic surgery under thoracic epidural anaesthesia

Exclusion Criteria

Contra-indications for thoracic epidural:
* Infection of the skin in the area of the epidural site
* A history of neurological diseases
* A history of bleeding diathesis
* Muscle diseases
* Hypersensitive to local anesthetics
History of Coronary Artery disease (CAD)
Known decreased ejection < 40 %
Known severe regurgitation or stenosis of a heart valve (grade 3 or 4)
Heart rhythm other than sinus rhythm
Existence of diabetes mellitus
Use of B-blockers or Calcium-antagonists
Pregnancy or lactation
Participation in a trial on investigational drugs within 3 months prior to the study

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>the first primary objective is the expected<br /><br>change in pulsed tissue Doppler systolic velocities of the mitral annulus (MV<br /><br>S*) during maximal exercise. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>CO: Cardiac output<br /><br>HR: Heart rate<br /><br>SBP<br /><br>DBP<br /><br>MAP<br /><br>MV A: Peak mitral inflow velocity during atrial contraction phase<br /><br>MV A: Mitral annular diastolic velocity during atrial contraction<br /><br>MV E: Peak mitral inflow velocity during early filling phase<br /><br>MV E: Mitral annular diastolic velocity during early filling<br /><br>MV E/A: Ratio of E to A<br /><br>MV E DT: Time interval required for the E velocity to decline from its peak to<br /><br>the baseline<br /><br>MV S: Mitral annular systolic velocity<br /><br>TV A: Peak tricuspid inflow velocity during atrial contraction phase<br /><br>TV A: Tricuspid annular diastolic velocity during atrial contraction<br /><br>TV E: Peaktricuspid inflow velocity during early filling phase<br /><br>TV E: Tricuspid annular diastolic velocity during early filling<br /><br>TV E/A: Ratio of tricuspid E to A<br /><br>TV S: Tricuspid annular systolic velocity</p><br>