THE EFFECT OF THORACIC EPIDURAL ANAESTHESIA WITH GENERAL ANAESTHESIA ON MEAN SYSTEMIC FILLING PRESSURE, VENOUS RETURN AND CARDIAC FUNCTIO

Completed

• Conditions: effecten van sympathicusblokkade door epidurale anesthesie met algehele anesthesie; epidural puncture; Thoracic epidural anesthesia

• Registration Number: NL-OMON40784
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-11-29
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 5

Inclusion Criteria

All adult patients scheduled for lung surgery under thoracic epidural and general anaesthesia

Exclusion Criteria

* Participation in a trial on investigational drugs within 3 months prior to the study
* Hemodynamic instability prior to start of measurements with the systolic blood pressure decreasing more than 30% below the pre-anaesthetic value or a mean arterial pressure (MAP) < 60 mm Hg, central venous pressure (CVP) >18 mm Hg and/ or a cardiac index < 2.0 L*min-1 or dependence on high dosages of inotropic drugs after induction of general anaesthesia and before TEA.
* Severe arrhythmias
* Intra-cardiac shunts
* Prior diagnosis of aberrant cardiovascular anatomy
* Symptomatic peripheral vascular disease
* Severe chronic obstructive pulmonary disease (GOLD III or IV, or proven existence of lung bullae)
* Clinically significant aortic aneurysm
* Significant valvular regurgitation
* Use of lithium medication
* Diabetes requiring insulin therapy
* On beta blocker or calcium antagonist medication
* Contra-indications to epidural anaesthesia: - Increased risk of bleeding induced by medication or bleeding disorders
- Local infection at the insertion site
- Anatomic abnormalities of the spine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objectives of this study consist of:<br /><br>- To evaluate the effects of thoracic epidural anaesthesia (TEA) under general<br /><br>anaesthesia on mean systemic filling pressures, arterial- and venous resistance<br /><br>and cardiac output.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives consist of:<br /><br>- To assess the hemodynamic effects of vasopressors and fluid loading under TEA<br /><br>with general anaesthesia conditions<br /><br>- To assess the value of stroke volume variation and pulse pressure<br /><br>variation,to predict fluid loading responsiveness with TEA.</p><br>