Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD

Not Applicable

Completed

• Conditions: Adolescent; Depression; Substance Use Disorders
• Interventions: Behavioral: Adolescent Coping With Depression/Functional Family Therapy

• Registration Number: NCT00680966
• Lead Sponsor: Oregon Research Institute

Brief Summary

The purpose of this study is to determine whether it is more effective to treat adolescents, with diagnoses of both depression and substance use disorder, with a treatment addressing the substance use first and then treating the depression or to first treat the depression and then treat the substance use or whether treating both disorders simultaneously is most effective.

It is expected that treatment of both disorders at the same time will be the most effective.

Detailed Description

Comorbidity is a well established aspect of adolescent psychopathology. The majority of adolescents entering treatment have more than one condition. This study will evaluate service delivery methods of integrating empirically supported interventions for depression and non-nicotine substance use disorders (SUD)in an effort to improve treatment engagement, response, and maintenance of gains. The two examined interventions are the Adolescent Coping With Depression course (ACWD) and Functional Family Therapy (FFT).

This study will expand upon previous research by systematically treating both depression and SUD. Over a 5 year period, 180 adolescents with depression/SUD and their parents/guardians will be recruited in Oregon and New Mexico and randomly assigned to 1 of 3 conditions: (a) FFT followed by ACWD, (b) ACWD followed by FFT, or (c) an intervention combining and augmenting FFT and ACWD (Integrated Treatment). Each treatment arm will consist of 24 sessions provided over 20 weeks. Participants will be assessed at intake, after the provision of 6, 12 (Mid-treatment), 18 and 24 (Post-treatment)treatment sessions, and at 6 and 12 month follow-ups.

Study Timeline

• Study Start: 2008-01
• Study First Submitted: 2008-05-16
• Study First Submitted QC: 2008-05-16
• Study First Posted: 2008-05-20
• Primary Completion: 2012-06
• Study Completion: 2013-06
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-10
• Last Update Posted: 2014-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

1. DSM-IV-TR diagnosis of depression, defined as MDD, dysthymia, or substance-induced mood disorder meeting MDD or dysthymia symptom criteria
2. DSM-IV-TR diagnosis of one or more non-nicotine SUD
3. Some reported illicit drug use in the last 90 days
4. 13-17 years of age
5. parent or guardian willing to participate in study
6. basic English competency (ability to converse in English)

Exclusion Criteria

1. Current and acute suicidal ideation at the level warranting inpatient treatment
2. current psychotic symptoms
3. the adolescent's sibling is already participating in the study
4. if on psychiatric medications, a significant change in dosage levels in the prior 4 weeks -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TX1	Adolescent Coping With Depression/Functional Family Therapy	Functional Family Therapy (FFT) followed by Adolescent Coping With Depression (ACWD)
TX 2	Adolescent Coping With Depression/Functional Family Therapy	ACWD (Adolescent Coping With Depression) followed by FFT (Functional Family Therapy)
TX 3	Adolescent Coping With Depression/Functional Family Therapy	Combination of an augmented FFT and ACWD - Integrated treatment

Primary Outcome Measures

Name	Time	Method
Children's Depression Rating Scale	Intake, Mid-Treatment, Post, 6 months and 12 months follow-up

Secondary Outcome Measures

Name	Time	Method
Time Life Follow Back	Intake, Mid-Treatment, Post, 6 months and 12 months follow-up

Trial Locations

Locations (1)

Oregon Research Institute; 🇺🇸 Eugene, Oregon, United States