Electrophysiological Characteristics and Anatomical Differentiation of Epileptic and Non-epileptic Myoclonus.

Completed

• Conditions: Myoclonus; Evoked Potential
• Interventions: Diagnostic Test: Somatosensory evoked potential

• Registration Number: NCT04235452
• Lead Sponsor: Mansoura University Hospital

Brief Summary

This study was conducted on a series of patients with myoclonus to identify the electrophysiological characteristics and the anatomical classification of myoclonus of different causes.

Detailed Description

The current study included 50 patients with different types of myoclonus in comparison to 30 control subjects. Electrophysiological study was done for all patients by Somatosensory Evoked Potential (SSEP) and Electroencephalography (EEG) while the control group underwent SSEP. SSEP was studied in the patients and control group by stimulation of right and left median nerves.

Study Timeline

• Study Start: 2018-11-01
• Primary Completion: 2019-08-31
• Study Completion: 2019-10-31
• Status Verified: 2020-01
• Study First Submitted: 2020-01-16
• Study First Submitted QC: 2020-01-16
• Last Update Submitted: 2020-01-16
• Study First Posted: 2020-01-22
• Last Update Posted: 2020-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Myoclonus classified into primary and secondary myoclonus.

Exclusion Criteria

• Psychiatric comorbidity to exclude psychological myoclonus.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Epileptic myoclonus	Somatosensory evoked potential	Juvenile Myoclonic Epilepsy and Progressive Myoclonic Epilepsy
Non-epileptic myoclonus (secondary)	Somatosensory evoked potential	Post hypoxic myoclonus, Post ischemic stroke myoclonus, Hepatic, Chronic kidney disease, and Drug induced myoclonus

Primary Outcome Measures

Name	Time	Method
Somatosensory evoked potential	24-72 hours	Stimulation of the right and left median nerves for each subject were carried out with electrical square wave pulses of 0.2 ms duration applied at a rate of 5 HZ. with cathode proximally. The intensity of the stimulus was adjusted to produce minimal twitches of the thumb (1-2 cm thumb movement). Five hundred (500) stimuli were delivered. The recording electrode picked up the responses. They were then summated and averaged.; The final evoked potential was then displayed on the screen. When two reproducible SEPs responses were obtained the data was accepted for analysis. The graph was printed out on paper, for the purpose of simplification only one response was printed out.

Trial Locations

Locations (1)

Mansoura University Hospital; 🇪🇬 Mansoura, Dakahlia, Egypt