Differentiating the mechanism of action of anti-TNF alpha agents

Not Applicable

Completed

• Conditions: Rheumatoid arthritis; Musculoskeletal Diseases

• Registration Number: ISRCTN44880063
• Lead Sponsor: HS Greater Glasgow and Clyde/University of Glasgow (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-01-10
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Adults with established active rheumatoid or psoriatic arthritis.

Exclusion Criteria

Prinicipal exclusion criteria in accord with clinical use of anti-TNF inhibitors.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of the two different anti-TNF inhibitors on mRNA and cytokine protein expression in rheumatoid arthritis and psoriatic arthritis: <br>1. mRNA, measured at week 0, 4, and 12<br>2. Cytokines, measured at week 0, 4, and 12