A comparison of efficacy of preoperative ketamine nebulization versus budesonide nebulization in reducing the incidence and severity of sore throat postoperatively after general anaesthesia with endotracheal intubation :A prospective randomized double blind study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Primary outcome assessed was incidence and severity of post operative sore throat(POST).
研究概览
简要总结
Various drugs have been compared to study their effectiveness in decreasing the incidence and severity of post operative sore throat(POST) in patients undergoing endotracheal intubation under general anesthesia .in this randomized double blind study, 100 patients were randomly divided into two groups group K (50) and group B (50) who will receive 2ml of 100 mg ketamine with 3ml of saline nebulization and 2ml of 0.5 mg budesonide solution with 3ml saline nebulisation .Budesonide is inhaled steroid that has decreases inflammation of airways .the main aim of the study is to compare between the two study drugs which decreased the incidence and severity of POST. Post operative hoareseness and cough between the two study drugs will be compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.ASA1 & ASA2 physical status patients aged between 18 to 65yrs admitted for elective surgery under general anaesthesia with endotracheal intubation with modified mallampatti score(MMP) I &II 2.Patients undergoing surgeries lasting less than 3hrs duration were selected for the study.
排除标准
- •1.Patients with history of sore throat.
- •2.Patients on long term anti-inflammatory analgesic medications.
- •3.Patients who have undergone insertion of devices which stimulate oral cavity, larynx, pharynx like nasogastric tube, endoscopic nasobiliary drainage tube.
结局指标
主要结局
Primary outcome assessed was incidence and severity of post operative sore throat(POST).
时间窗: 0 hour,,4 hour,8 hour,12 hour,24 hour
次要结局
- Incidence of post operative hoarseness and cough(0,4,8,12,24 hours)
研究者
Dr Meda Venkata Srinivas
Government Medical College,Cuddapah