Effect of intravenous dexmedetomidine and remifentanil on cardiovascular response to extubatio

Phase 3

Recruiting

Conditions: Elective surgery.
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
Y83.9

Registration Number: IRCT20200825048515N74

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

Candidate for elective surgery under general anesthesia
Age range from 20 to 60 years
American Society of Anesthesiologists (ASA) class equal to 1 or 2
Weight 55 to 85 kg (body mass index 18.5-24.9 kg/m2)
Consent to participate in the study

Exclusion Criteria

Pregnancy
Having underlying diseases (including diabetes, chronic lung disease, cardiovascular disease, uncontrolled blood pressure, kidney failure)
Having a heart rate of less than 60 beats/minute or a systolic blood pressure of less than 90 mmHg upon entering the study.
Having an allergy to the drugs used
Drug use

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Systolic blood pressure. Timepoint: Before induction of anesthesia, before extubation, 1, 3, 5, and 10 minutes after extubation. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before induction of anesthesia, before extubation, 1, 3, 5, and 10 minutes after extubation. Method of measurement: Monitoring device.;Heart rate. Timepoint: Before induction of anesthesia, before extubation, 1, 3, 5, and 10 minutes after extubation. Method of measurement: Monitoring device.;Oxygen saturation (SPO2). Timepoint: Before induction of anesthesia, before extubation, 1, 3, 5, and 10 minutes after extubation. Method of measurement: Monitoring device.

Secondary Outcome Measures

Name	Time	Method
Tachycardia. Timepoint: before induction of anesthesia, before extubation, 1, 3, 5, and 10 minutes after extubation. Method of measurement: Heart rate more than 100 beats per minute.;Bradycardia. Timepoint: before induction of anesthesia, before extubation, 1, 3, 5, and 10 minutes after extubation. Method of measurement: Heart rate less than 60 beats per minute.;Cough. Timepoint: After extubation. Method of measurement: Observation.;Laryngospasm. Timepoint: After extubation. Method of measurement: Observation.;Hypoxia. Timepoint: After extubation. Method of measurement: Oxygen less than 60 bpm.