Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes

Not Applicable

Completed

• Conditions: Acute Coronary Syndromes; Coronary Artery Disease

• Registration Number: NCT00716352
• Lead Sponsor: Royal Brompton & Harefield NHS Foundation Trust

Brief Summary

This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated, half received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months. Longer term follow up through the Office Of National Statistics will be performed.

Detailed Description

This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated. A cluster randomised method was used and half of centres received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months and longer term follow up for mortality will be performed through the national databases.

Study Timeline

• Study Start: 2004-03
• Study Completion: 2005-11
• Status Verified: 2008-07
• Study First Submitted: 2008-07-15
• Study First Submitted QC: 2008-07-15
• Last Update Submitted: 2008-07-15
• Study First Posted: 2008-07-16
• Last Update Posted: 2008-07-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1340

Inclusion Criteria

All patients admitted to the hospital (either through casualty or directly to the wards), with a good clinical history of an acute coronary syndrome with one or more of the following:

1. Ischaemic changes on the admission ECG (including patients with bundle branch block)
2. Elevated Troponin or cardiac enzymes on admission
3. Normal ECGs but with evidence of pre-existing coronary artery disease i.e., evidence of a prior history of MI, coronary revascularisation, coronary angiography demonstrating the presence of significant coronary stenosis or a stress test demonstrating ischaemia (treadmill, echo or nuclear scan)

Written informed consent

Exclusion Criteria

1. Patients with persistent ST elevation >1mm in two or more contiguous leads on the ECG.
2. Patients treated with thrombolytic therapy, or for whom thrombolytic therapy was considered on admission.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Adherence to the educational programme measured by the frequency of use of the evidence based treatments: Aspirin, Heparin, Clopidogrel, Beta blockers, Statins.

Secondary Outcome Measures

Name	Time	Method
Comparison of investigations and tests
Use of other treatments
Counselling for lifestyle changes
Referral to smoking cessation clinics
Cardiac rehabilitation
Compliance to treatment at 6 months
Comparison of clinical events at 6 months

Trial Locations

Locations (37)

University Hospital Aintree; 🇬🇧 Aintree, United Kingdom

Monklands Hospital; 🇬🇧 Airdrie, United Kingdom

Antrim Hospital; 🇬🇧 Antrim, United Kingdom

Barnet General Hospital; 🇬🇧 Barnet, United Kingdom

Barnsley District General Hospital; 🇬🇧 BArnsley, United Kingdom

Basildon Hospital; 🇬🇧 Basildon, United Kingdom

North Hampshire Hospital; 🇬🇧 Basingstoke, United Kingdom

Mater Infirmorum Hospital; 🇬🇧 Belfast, United Kingdom

Royal Victoria Hospital; 🇬🇧 Belfast, United Kingdom

Birmingham Heartlands Hospital; 🇬🇧 Birmingham, United Kingdom

Scroll for more (27 remaining)