Investigating Intra-hepatic Fatty Acid Partitioning and Its Regulation in Man. Studies to Understand the Role of Dietary Nutrients in Liver Fat Metabolism in Relation to Obesity in Man.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Plasma triglyceride concentrations
研究概览
简要总结
High levels of fatty substances in the blood increase the risk of developing heart disease. Investigators know a lot about one of these fatty substances, cholesterol. However, there is another fatty substance in the blood called triglyceride. Investigators do not understand much about what regulates the rate at which the liver produces triglyceride and liberates it into the bloodstream after eating a meal(s). It is known that taking fish oil lowers the amount of blood triglyceride however, it remains unclear how this happens. Investigators will study if changes in liver fat metabolism, after taking fatty acids found in fish oil (n-3 fatty acids)can explain the lowering of blood triglyceride. Investigators also want to know if taking fish oil alters the amount of fat that accumulates within the liver.
详细描述
Investigators will recruit men and women with no medical condition or relevant drug therapy that affects liver fat metabolism.
Purpose and design:
Investigators are asking the research question: "How do specific fatty acids, such as those found in fish ((n-3) fatty acids) influence postprandial liver fat metabolism?"
It is known that n-3 fatty acids lower plasma triglyceride concentrations but it remains unclear how this happens.
To address this research question investigators want to undertake detail physiological studies, in a randomised study where individuals will be studied before and after taking n-3 fatty acids or a placebo oil.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is willing and able to give informed consent for participation in the study.
- •BMI >19 <35kg/m2
- •No medical condition or relevant drug therapy known to affect liver metabolism
排除标准
- •Age <18 or >65 years
- •Body mass index <19 or >35kg/m2
- •A blood haemoglobin <120mg/dL
- •Any metabolic condition or relevant drug therapy
- •People allergic to fish / seafood or nuts
- •History of alcoholism or a greater than recommended alcohol intake
- •Pregnant or nursing mothers
- •Women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months
- •History of severe claustrophobia
- •Presence of metallic implants, pacemaker
- •Haemorrhagic disorders
- •Anticoagulant treatment
结局指标
主要结局
Plasma triglyceride concentrations
时间窗: Eight weeks
Investigators will measure plasma triglyceride concentrations at baseline and 8 weeks after taking n-3 fatty acids or a placebo.
次要结局
- Hepatic fatty acid partitioning(Eight weeks)