A clinical trial to compare the effectiveness of repeated ketamine infusions and electroconvulsive therapy in patients of depression with suicidality and how it relates to the kynurenine pathway.
Not Applicable
- Conditions
- Health Condition 1: F322- Major depressive disorder, singleepisode, severe without psychotic features
- Registration Number
- CTRI/2021/07/035210
- Lead Sponsor
- Central Institute of Psychiatry Ranchi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
â?ªPatients fulfilling ICD 10- DCR diagnostic criteria for â??unipolar(single or recurrent) non-psychotic depressive episodeâ??
�Patients who are drug naïve or drug free for 2 weeks on antidepressants or 4 weeks for fluoxetine.
â?ªPatients giving written informed consent
â?ªPatients with suicidal ideation and behaviors are evaluated using the BSI (score>=6 has been used as a cutoff threshold for clinically significant suicidal ideation according to literature).
Exclusion Criteria
â?ªDepressive episodes with psychotic symptoms.
â?ª Any other major co-morbid psychiatric diagnosis and substance dependence excluding nicotine & caffeine
â?ªPresence of an acute/unstable medical or neurological condition
â?ªPregnancy or lactation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method