A clinical trial to compare the effectiveness of repeated infusions of Ketamine and Midazolam in Obsessive Compulsive disorders that have not responded to previuous treatments with medicines or psychotherapy, and to see how this relates to the Brain Dericed Neurotrophic Factor(BDNF).
Phase 2
- Conditions
- Health Condition 1: F42- Obsessive-compulsive disorder
- Registration Number
- CTRI/2021/07/035229
- Lead Sponsor
- Central Institute of Psychiatry CIP
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients of either sex, aged between 21-50 years.
2. Inpatients fulfilling ICD 10-DCR diagnostic criteria for OCD but are treatment non-responders.
3. Patients giving written informed consent.
Exclusion Criteria
1. Any other major co-morbid psychiatric diagnoses (except depression and mild to moderate anxiety) and substance dependence excluding nicotine & caffeine.
2. Presence of an acute/unstable medical or neurological condition.
3. Pregnancy or lactation.
4. Childhood onset OCD (age at onset <10 years) [Geller et al, 1998].
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method