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临床试验/NCT06465407
NCT06465407尚未招募不适用

Effect of Collagen Protein Versus Placebo on Indirect Markers of Musculotendinous Unit Recovery Following Eccentric Plantar Flexor Exercise

University of Central Florida2 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2024年7月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
36
试验地点
2
主要终点
Calf muscle thickness

研究概览

简要总结

This study is focused on exploring the gap in the literature by comparing the effects of collagen protein versus placebo supplementation on the musculotendinous unit following muscle damaging protocol. Thus, the purpose of this study is to identify and compare the effect of collagen protein versus placebo supplementation on indirect markers of musculotendinous unit recovery following eccentric calf exercises.

详细描述

Various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, will consume a daily dose of two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan) or placebo (30 g of pure maltodextrin with no amino acids) mixed in 300 ml of orange Gatorade zero.

Gatorade zero, maltodextrin, and collagen is going to be stored in the locked cabinet in the lab. Research team will mix the supplement (placebo or maltodextrin) with Gatorade zero in a non-clear bottle and will administer it to the participants on-site.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Basic Science
盲法
Single (Participant)

盲法说明

Single blind repeated measures design. Participants will be blinded to the intervention while research team will not be blinded and will be mixing supplements.

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Males between the ages of 18-30 years old
  • Determined to be healthy by PAR-Q+ and the HHQ

排除标准

  • Untrained (no resistance training in the past 3 months)
  • Any response of "yes" on the PAR-Q+; exclusion criteria noted on the HHQ
  • Allergy to bovine collagen or maltodextrin

结局指标

主要结局

Calf muscle thickness

时间窗: 5 days

Portable B-mode Ultrasound (GE Logiq e BT12, GE Healthcare, Milwaukee, WI, USA) and a multi-frequency linear- array probe (12 L-RS, 5-13 MHz, 38.4-mm field of view, GE Healthcare, Milwaukee, WI, USA) will be used to determine changes in muscle thickness of the randomized leg. The distance between the medial point of the knee joint space and the central point of the medial malleolus will be measured at 70% and ultrasound gel will be placed on this location prior to measurement. The highest and mean values of 3-5 measurements will be recorded for each assessment. All measurements will be done on one randomized leg.

次要结局

  • Achilles tendon thickness.(5 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ecaterina Vasenina

Graduate Research Associate

University of Central Florida

研究点 (2)

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