Effect of prebiotic and probiotic mixture in the treatment of pediatric non-alcoholic fatty liver disease (NAFLD)
Not Applicable
Completed
- Conditions
- Obese children with NAFLD
- Registration Number
- TCTR20170128001
- Lead Sponsor
- The Ratchadaphiseksomphot Fund, Faculty of Medicine, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Obese children with NAFLD, age 6 to 18 years
- Obese is defined by weight more than 2SD in the same gender
and same age.
- NAFLD is defined by the presence of steatosis with controlled attenuation parameter (CAP) values ≥250 dB/m from Fibroscan with CAP.
Exclusion Criteria
1.Fatty liver from metabolic liver disease, viral hepatitis, Wilson disease, autoimmune hepatitis
2.History of hepatotoxic drug or substance used
3.Allergic or serious ADR to probiotics and prebiotics
4.Poor compliance
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hepatic fat content 16 weeks controlled attenuation parameter (CAP) by fibroscan
- Secondary Outcome Measures
Name Time Method iver fibrosis 16 weeks Liver stiffness measurement (LSM) by fibroscan,Body mass index Z-score 16 weeks 2007 WHO child growth references