peri-IMplantation Profile of Endometrial Transcriptio

Completed

Conditions: 10046828
recurrent implantation failure
10014701

Registration Number: NL-OMON38230

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 150

Inclusion Criteria

All groups:
- age from 18 till 38 years at moment of IVF or ICSI treatment
- regular mentrual cycle ( 25-35 days);Study group:
Women who have not achieved a pregnancy, despite at least three fresh embryo transfers in an IVF or ICSI treatment.
- An abortion will be regarded as a pregnancy.
- A chemical pregnancy will not be regarded as a pregnancy.;Control group
Women who conceived after the first or second ICSI treatment for male factor infertility and who have delivered a healthy baby.;Reference group
Women who conceived and have delivered a healthy baby within three IVF attempts.

Exclusion Criteria

All groups:
- Use of oral anticonceptives or an intra-uterine device
- Difficulty in communicating in Dutch or English
- Poor ovarian response after adequate ovarian stimulation
- Smoking;Study group
- PESA (percutaneous epididymal sperm aspiration) / MESA (microsurgical epididymal sperm aspiration / TESE (testicular sperm extraction)
- Abortion following the IVF or ICSI treatment
- A known cause of recurrent implantation failure detected during pre-inclusion screening.
- Poor embryo quality;Control group
- Other causes of infertility than severe male infertility.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Validation of our initial findings of a molecular signature which can be<br /><br>distinguish between normally receptive and less-receptive endometrium<br /><br>(06/101/K) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To identify differences between normally receptive and less-receptive<br /><br>endometrium by protein expression.<br /><br>- To implement our findings of the molecular signature in the IVF patient<br /><br>population. Comparing gene expression results betweeen IVF patients that<br /><br>conceived within 3 IVF attempts and patients who didn't ( implantation<br /><br>failure).</p><br>