Effect Of Micronised Progesterone On Endometrial Receptivity

Active, not recruiting

• Conditions: infertile patients with polycystic ovaries and unexplained infertility; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12610000195055
• Lead Sponsor: ISTANBUL UNIVERSITY RESEARCH FUND

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-03-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

INFERTILE PATIENTS OF POLYCYSTIC OVARIES AND UNEXPLAINED INFERTILITY
20-39 YEARS OLD
NO SYSTEMIC DISEASES

Exclusion Criteria

INFERTILITY OTHER THAN polycystic ovaries(PCO) AND UNEXPLAINED,SYSTEMIC DISEASES,DRUG USERS,OVARIAN OR ENDOMETRIAL PATHOLOGIES SUCH AS MYOMA,ENDOMETRIOSIS

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We will take endometrrial biopsies from all participants by pipelle at mid-secretory period and fixe with formaline and then embed in paraffin block.After all samples collected immunohistocchemical staining and investigation and scorring under microscopy will be performed for the following;<br>Estrogen receptor<br>Progesterone receptor<br>Glycodelin<br>Interleukine(IL) 11<br>Leukaemia inhibitory factor (LIF), all these will be obtained as commercial antibody kits by abcam.[at 2 months post-intervention]

Secondary Outcome Measures

Name	Time	Method
chemical pregnancy rate;will be detected by blood beta human chorionic gonadotrophin(HCG) measurement after the menstreal delay for 3 days<br>clinical pregnancy rate; which will be detected by transvaginal ultrasonography after the menstruel delay of 7 days.[at 2 months post-intervention]