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Clinical Trials/ISRCTN98001632
ISRCTN98001632
Completed
Not Applicable

on-invasive assessment of haemodynamic response to beta-blockers using magnetic resonance imaging in patients with portal hypertension

niversity of Edinburgh/ACCORD0 sites20 target enrollmentMay 19, 2017
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Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
niversity of Edinburgh/ACCORD
Enrollment
20
Status
Completed
Last Updated
8 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
May 19, 2017
End Date
TBD
Last Updated
8 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity of Edinburgh/ACCORD

Eligibility Criteria

Inclusion Criteria

  • •1\. Male or female patients aged 18\-80 with liver cirrhosis
  • •2\. Portal hypertension in whom commencement of beta\-blockers is clinically indicated

Exclusion Criteria

  • •1\. Contraindication to Beta\-Blocker therapy (such as moderate to severe asthma)
  • •2\. Contraindication to MRI scan
  • •3\. Contraindication to administration of gadolinium\-based MRI contrast (including eGFR \<30mL/min)
  • •4\. Concomitant use of other vasoactive drugs (e.g. nitrates, phosphodiesterase inhibitors)
  • •5\. Previous TIPSS insertion
  • •6\. Portal vein thrombosis
  • •7\. Hepatocellular carcinoma
  • •8\. Pregnancy or breastfeeding
  • •9\. Inability to obtain informed consent (e.g. refusal/overt hepatic encephalopathy)

Outcomes

Primary Outcomes

Not specified

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