Does Aprepitant (Emend ®) influence fentanyl PK?
Completed
- Conditions
- All patients using a stable dose of a fentanyl (Durogesic ®) patch (for at least 8 days, to guarantee steady state).
- Registration Number
- NL-OMON21924
- Lead Sponsor
- Erasmus Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 14
Inclusion Criteria
age >= 18 years;
- stable use and dose of fentanyl patch (Durogesic ®) for at least 2 weeks irrespective of the dose used;
Exclusion Criteria
- Using fentanyl as rescue medication (other opioids are allowed)
- serious psychiatric illness, confusion of intellectual disability
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fentanyl pharmacokinetics (i.e.clearance).
- Secondary Outcome Measures
Name Time Method - side effects according the CTC toxicity criteria<br /><br>- differences in pain intensity according the NRS <br>