Efficacy of Adjunctive Cerebellar Transcranial Alternating Current Stimulation in Negative Symptoms of Schizophrenia
- Conditions
- Health Condition 1: F209- Schizophrenia, unspecified
- Registration Number
- CTRI/2023/10/058415
- Lead Sponsor
- Central Institute of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Diagnosis of Schizophrenia using International Classification of Diseases-11th edition
(ICD-11) (WHO, 2019).
2. Patients giving written informed consent.
3. Right-handed patients.
4. Illness duration of equal to or more than 2 years.
5. The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) with negative
symptoms score of more than 15.
6. Scale for Assessment of Negative Symptoms (SANS) score more than 20.
7. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7.
1. Presence of co-morbid neurological or other psychiatric disorder(s).
2. Patient with co-morbid substance dependence, except nicotine and caffeine.
3. Patients having any metallic implants in the body.
4. Subjects who have received ECT in past 1 month.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebellar theta tACS results in a change in the negative symptoms at the end of 10 sessions.Timepoint: Improvement in the scores of PANSS, SANS, CGI at the end of 10 sessions(2 weeks) & 6 weeks as compared to baseline.
- Secondary Outcome Measures
Name Time Method Changes in the levels of GABA, Glutamate, Glutamine, NAA & NAAG in cerebellum using Proton MR Spectroscopy post theta tACS administration to cerebellum.Timepoint: Baseline, at the end of 10 theta tACS sessions(2 weeks).