Effects on blood pressure of conventional strength training, handgrip training and combined training (strength training + handgrip training)
- Conditions
- HypertensionC14.907.489
- Registration Number
- RBR-4fgknb
- Lead Sponsor
- Escola de Educação Física e Esporte da Universidade de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- Not specified
Men between 30 and 65 years old; with diagnosis of hypertension and under antihypertensive medication with drug and dose maintained at least in then previous 4 months; not taking anti-hypertensive drugs that directly affect cardiac autonomic regulation (such as beta-blockers and non-dihydropyridine calcium channels inhibitors); not practicing physical exercise more than twice a week or more than 150 minutes/week; no resistance exercise practice in the previous 6 months.
Presence of secondary hypertension and/or target-organ lesion; systolic/diastolic blood pressures equal to or greater than 160/105 mmHg; obesity level II or superior; other cardiovascular diseases besides hypertension; diabetes with complications or in use of insulin; presence of osteoarticular diseases that limit resistance exercise execution; electrocardiographic alterations during maximal exercise test that suggest cardiovascular diseases; change in dose or medication during the protocol.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease of clinic blood pressure measured by<br>auscultatory technique with a minimum<br>reduction of 4 mmHg<br><br><br> <br><br> <br><br>;Decrease of ambulatory blood pressure measured by oscillometric technique with a minimum<br>reduction of 3 mmHg;Decrease of exercise blood pressure measured by<br>photoplethysmographic technique with a minimum<br>reduction of 3 mmHg
- Secondary Outcome Measures
Name Time Method Improvement of cardiovascular autonomic<br>modulation, as evidenced by the increase<br>of heart rate variability, reduction of<br>blood pressure variability and increase in baroreflex sensitivity measured with spectral analysis.;Improvement of the endothelial function<br>verified by the flow-mediated dilation<br>technique (FMD) with a minimum increase<br>of 4% in artery diameter between the initial<br>and final evaluations;Reduction in peripheral vascular resistance<br>based on calculus considering the cardiac<br>output measured by the CO2 rebreathing<br>technique from a minimum 7% reduction<br>between the initial and the final evaluations.