Pain sensitivity in children and adults with Down syndrome: do they have altered pain thresholds and tolerance?

• Conditions: verstandelijk handicap; Down syndrome and pain sensitivity; 10042258

• Registration Number: NL-OMON30552
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 96

Inclusion Criteria

Index group: Trisomy 21, (biological age 10-12 and 20-22 year-old). Both groups have a social and communicative adaptation behaviour corresponding with that of children without CI of >=7 years, i.e. total score on the Vineland-Z social domain >=97 and a total score on the Vineland-Z communication domain >=93
Reference subjects: children with a biological age of 7-12 years and young adults with a biological age of 20-22 years.

Exclusion Criteria

Index group: not able to tell what pain is and when they suffered pain, not responsible to reproduce the instructions given for testing, any record of behavioural or language problems, or use of anti-epileptics, anti-depressives, or spasmolytics.
Reference groups: mental handicap, or use of anti-epileptics, anti-depressives, or spasmolytics.

Study & Design

• Study Type: Interventional
• Study Design: Not specified